What is cardiovascular disease?
If you have had any of the following "events" you have cardiovascular disease (CVD):

HEART ATTACK OR ANGINA, STROKE OR TIA*, CORONARY SURGERY OR ANGIOPLASTY.

CVD usually occurs as the result of atherosclerosis. People with atherosclerosis have cholesterol build-ups, often called atherosclerotic plaques, on the walls of blood vessels in their heart or brain. These plaques take a number of years to develop, but as they grow, they gradually block the flow of blood through the artery. *TIA = Transient Ischemic Attack

  A CLOSE LOOK AT ATHEROSCLEROSIS IN CORONARY ARTERIES  
  Normal coronary artery with no atherosclerosis Mild coronary atheroscelerosis Moderate coronary atherosclerosis Occlusive coronary atherosclerosis Severe coronary atherosclerosis, involving 100% of the surface of the artery.  
  NORMAL CORONARY ARTERY WITH NO ATHEROSCLEROSIS.

It can carry as much blood as the heart requires.

MILD CORONARY ATHEROSCLEROSIS.

The blockage is not yet big enough to cause problems.

MODERATE CORONARY ATHEROSCLEROSIS.

The artery is narrowed by half. From now on, the heart is under strain because it is not getting all the blood it needs. There is also the risk of a blood clot forming as blood squeezes through the small gap.

OCCLUSIVE CORONARY ATHEROSCLEROSIS.

The artery is narrowed by 60 to 70%. The chances of a blood clot forming are high, and the heart will be having difficulty getting the blood it needs. You may experience angina (heart pain).

SEVERE CORONARY ATHEROSCLEROSIS. INVOLVING 100% OF THE SURFACE OF THE ARTERY.

A blood clot is highly likely, which would stop blood flow to the heart (a heart attack).

 
  Adapted from Pepine CJ. Am J. Cardiol 1998; 82 (Suppl IOA) : 235-275.  

 

Lipitor Consumer Mandatories:

LIPITOR® (atorvastatin calcium) is a prescription medicine used to lower high cholesterol levels and to help reduce the risk of having a heart attack or stroke. Consult your doctor to see if this medicine is right for you. Do not take this medicine if you have liver disease, are pregnant or intend to become pregnant, if you are breastfeeding, or have an allergy to the active ingredient (atorvastatin) or other tablet ingredients. Precautions: people who consume large quantities of alcohol and/or have a history of liver problems; people who have muscle pain, tenderness or weakness; patients who have had a type of stroke called a haemorrhagic stroke or a type of stroke called a lacunar infarct. There are some medicines that may interfere with LIPITOR. These include digoxin, antibiotics (erythromycin, clarithromycin, rifampicin), phenytoin, oral contraceptives, cyclosporin, medicines used to treat HIV infection (efavirenz, protease inhibitors), treatments for fungal infections, diltiazem and other medicines used to treat high cholesterol or triglycerides. Caution should be exercised if a HMG-CoA reductase inhibitor is administered concomitantly with other drugs that may decrease the levels or activity of endogenous steroid hormones such as ketoconazole, spironolactone and cimetidine. Excessive quantities of grapefruit juice may interfere with LIPITOR. Possible side effects: headache, abdominal pain, nausea, constipation, diarrhoea, difficulty sleeping and muscle pain, tenderness or weakness. If you have side effects see your doctor. Always read the label and use strictly as directed. LIPITOR® is fully funded under special authority. Contains atorvastatin 10mg, 20mg & 40mg. Further medicine details are available at www.medsafe.govt.nz. Pfizer New Zealand LTD PO Box 3998, Auckland, 0800 675229, www.pfizer.co.nz ®Registered Trademark

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